Zepteon: Separation of Nonfucosylated Antibodies Zepteon, Inc. is a privately held corporation founded in 2012 that has developed first in class purification tools capable of separating antibodies with specific sugar structures (nonfucosylated) that are more potent against diseases like cancer. The products have been bought and used by more than half of the largest pharmaceutical companies. Zepteonís Glycap-3A chromatography resin can be used to make a biosimilar antibody with a nonfucose level that matches that of the original drug, or one with a nonfucose level at the upper end of the range of the original drug to differentiate it from other biosimilars on the market. The resin could also be used to make a biobetter antibody that has a far higher nonfucose level than the original antibody. Zepteon chromatography resins can be used to prepare material to evaluate the effects of a wide range of nonfucosylation levels in studies of antibody function. The technology can also be used analytically, for example, to determine antibody nonfucosylation levels as a function of cell culture conditions. The Zepteon technology can therefore enable preparation of a robust biosimilar antibody filing, increasing the chances of regulatory success and increasing speed to market. The economical, fast and robust Zepteon separation method is superior to cellular methods of targeting fucose levels. Cellular methods like genetically engineering cells or screening cell lines and bioreactor conditions are slow, complex and costly.